hrp0084p1-135 | Turner & Puberty | ESPE2015

Sex Hormones and Gonadal Size in Pubertal Girls Born Small or Appropriate for Gestational Age

Petraitiene Indre , Verkauskiene Rasa , Jariene Kristina , Vitkauskiene Astra

Background: Small for gestational age (SGA) birth size has been associated with various metabolic, hormonal and reproductive problems in later life.Objective and hypotheses: We aimed to compare differences in sex hormones, uterine and ovarian sizes in SGA and appropriate for gestational age (AGA) adolescent girls.Method: 23 SGA and 47 AGA pubertal 11–14 years old girls (median age 13.2±1.94 years, median pubertal stage 4&...

hrp0084p2-381 | Fat | ESPE2015

Metformin in Combination with Lifestyle Changes Effectively Reduces BMI and Waist Circumference in Overweight/Obese Children and Adolescents

Smetanina Natalija , Seibokaite Adrone , Valickas Raimondas , Kuprionis Gintaras , Grigoniene Jolanta Janina , Rokaite Ruta , Vitkauskiene Astra , Albertsson-Wikland Kerstin , Verkauskiene Rasa

Background: Overweight (OW) and obesity in paediatric population has been shown to be associated with an increase in prevalence of insulin resistance and type 2 diabetes (T2D) in youth.Objective and hypotheses: The aim of this study was to assess the efficiency and safety of metformin use in combination with lifestyle changes or alone for weight management in OW and obese (OB) children and adolescents.Methods: Study included 145 10...